Monday, July 31, 2017

NEWS POST: The Story Of How A Worm Turned... Into A Bringer Of Medical Miracles

Marine worms may hold the key to medical breakthroughs including speedier recovery from surgery and more blood transfusions
For centuries, the only use humans found for the lugworm -- dark pink, slimy and inedible -- was on the end of a fish hook.

But the invertebrates' unappreciated status is about to change.

Their blood, say French researchers, has an extraordinary ability to load up with life-giving oxygen.

Harnessing it for human needs could transform medicine, providing a blood substitute that could save lives, speed recovery after surgery and help transplant patients, they say.

"The haemoglobin of the lugworm can transport 40 times more oxygen from the lungs to tissues than human haemoglobin," says Gregory Raymond, a biologist at Aquastream, a fish-farming facility on the Brittany coastline.

"It also has the advantage of being compatible with all blood types."

Raymond and his team, which specializes in fish egg production, joined forces with biotech firm Hemarina in 2015 in the hope of securing a reliable means of lugworm production.

The facility now churns out more than 1.3 million of the creatures each year, each providing tiny amounts of the precious haemoglobin.

"We started basically from zero. Since the worm had never been studied, all parameters needed inventing from scratch, from feeding to water temperature," says project researcher Gwen Herault.

Medical interest in the lugworm -- Arenicola marina -- dates back to 2003, when the outbreak of mad-cow disease in Europe and the worldwide HIV epidemic began to affect blood supplies.

The problem was that animal haemoglobins, as a substitute for the human equivalent, can cause allergic reaction, potentially damaging the kidneys.

In lugworms, though, haemoglobin dissolves in the blood and is not contained within red blood cells as in humans -- in other words, blood type is not an issue -- and its structure is almost the same as human haemoglobin.

In 2006, the worm's potential was validated in a major study.

Scientists at Roscoff, close to Plomeur, extracted and purified haemoglobin from local-caught lugworms and tested it on lab mice. The rodents were fine and showed no sign of the immune response that dogged other animal substitutes.

If proven safe for humans, the researchers said, the worms' oxygen-rich blood could tackle septic shock -- a crash in blood pressure that can cause fatal multiple organ failure -- and help to conserve organs for transplantation.

Clinical trials of the blood product began in 2015. Lugworm haemoglobin was used last year in 10 human kidney transplants at a hospital in the western French city of Brest and 60 patients are currently enrolled in tests of the blood product across France.

Marine worms are better known as providing bait for fishermen
- Male or female? -
The secrets of lugworm haemoglobin lie in its ability to survive in extreme conditions, burrowing into sand at the edges of the tide.

The worm grows to about 25 centimetres (10 inches) in length and has several bushy external gills along its body.

At high tide, submerged in water, the worm builds up stocks of oxygen that, astonishingly, allow it to survive more than eight hours out of the water at low tide.

Anyone who has walked along a sandy beach at low tide will see evidence of lugworms, from the tiny coiled casts of sand they throw up from their burrow, 10 cms below the surface.

But, apart from anglers who dig up the creatures for bait, lugworms are rarely seen -- and breeding them is a novel challenge.

"The main difficulty is working with a small animal that lives its life hidden," explained Raymond.

Aquastream struggled at first with basic rearing problems -- including how to tell a male lugworm from a female.

After nine months of testing, "50 percent of adult worms survived and a good deal of them produced eggs," said Herault.

The larvae start out around 1mm in length and the worms are transported to Hemarina's testing site once they reach 5mm.

Aquastream director Nathalie Le Rouilly said that her firm's collaboration with Hemarina could provide the world of medical science with a sustainable supply of the worms.

"There is nowhere else in France or the world that has the capacity to produce lugworms in a controlled environment to ensure a supply of their haemoglobin," she says.

Scientists are excited by the potential of lugworm haemoglobin -- although they also point to a rigorous testing procedure before the molecule can be certified as safe and effective for humans.

"The properties of extracellular haemoglobin extracted from the lugworm could help protect skin grafts, promote bone regeneration and lead to universal blood," says Raymond.

If this vision turns real, lugworm blood may also allow donor organs to live longer outside the bodies, potentially helping thousands of recipients each year.

And, one day, freeze-dried lugworm blood could be a crucial backup for standard blood supplies -- a boon in combat zones or disasters.

Originally published on AFP/DAILY MAIL UK WIRES

Friday, July 28, 2017

NEWS POST: Mobile Money Is Only Just Starting To Transform Some Of Africa’s Markets

M-Pesa, the world's leading mobile money service in Kenya. (EPA/Daniel Irungu)
Edward Joseph Karemera, 39, a resident of Buikwe district in central Uganda, has been running a fish trading business between Rwanda and Uganda for eight years, he used to make the painstaking nine-hour journey by bus to Nyabugogo in Kigali, Rwanda which is the destination of his fish, from his stores on the shores of Lake Victoria in Kiyindi at least six times in a month. His commodities go by truck, but he also had to make the trips to receive payment for the supplies, which he would change into Uganda shillings and go back to buy more fish.

The business was becoming untenable because of the long trips, and despite working with the same customers for so long nothing could change, he had to personally pick his money.

But since the introduction of a cross-border money remittance service, his clients in Kigali now send him the money on his MTN Uganda mobile money account while he is in Uganda, he saves on the costs and his business has expanded.

Mobile money adoption in Africa outpaced growth in the rest of the world, with over half of all services globally and more than 40% of adults in active use 

Karemera says mobile money has been a boon for his business and can’t imagine living without mobile phones even though they only came available to him less than two decades ago. “My trade has become much easier and cost effective, its even easier dealing with workers now, anything I want I just send them money and they purchase it.”

The mobile money service has grown to include international inbound remittance transfers to other countries through partners like World Remit, Small World and Western Union.

Examples like Karemera’s support the notion that with a mobile phone, Africa has a real chance of overcoming lost years of underdevelopment.

Mobile money accounts in sub-Saharan Africa have surpassed bank accounts, says a report from global trade body GSMA. It gives a fighting chance for millions of un-banked rural poor to be financially included and benefit from products like savings and loans for their small and mostly informal businesses, money transfers, among others.

Analysts believe there is still plenty more ground to break by mobile money’s impact in Africa. Only 17% of the viable mobile money rural market has been tapped says GSMA, Tanzania for instance still has up to 92% of its people especially in rural areas still unbanked.

That said, mobile money adoption in the region outpaced growth in the rest of the world, contributing 140 mobile money services of the 277 global totals, and more than 40% of adults in the region use the service on an active basis, but it looks like this is just the beginning.

Telecom industry captains are not able to rest on their laurels, the current market dynamics are unforgiving they say. There is more pressure for telcos to generate revenue from additional services beyond voice and SMS even as the growing penetration of smartphones and internet means dwindling revenue growth caused by so called over-the top platforms disruption. More people are increasingly bypassing voice and SMS to use social medias like WhatsApp, Facebook and others, for both voice calls and instant messaging.

“Telecom operators have no choice but to capitalize on innovation and the scalable nature of mobile money” said Mats Granryd, the director general of GSMA, at the recent mobile 360 event in Dar Es Salaam.

The glossy numbers however only tell part of the story, the real equalizer effect of mobile money has been the impact of the innovation around financial services, where telecom players have churned out multiple use cases cutting across all economic divides in Africa, from simple ones like money transfer and air time top-up to more sophisticated ones like bill payments and bank-to mobile wallet transactions.

As more people overcome the digital cultural shock and become digitally literate they are shopping with tap & pay and other merchant payment solutions, while they also pay their utility bills, cable TV subscriptions and even taxes. Using mobile money significantly increases efficiencies, for instance Dar es Salaam water and sewerage cooperation registered a 38% increase in revenue collections when it started collecting it through mobile money.

Granryd also noted that telecoms have to develop more Non-communication services that ease life and solve problems, while consolidating the existing user-cases, that it is through these new revenue streams that the industry will stay afloat.

Mobile money has become a lifeline to unfortunate members of society, for instance up to 52% of refugees from Nyarugusu refugee camp in Tanzania use mobile money to receive humanitarian cash donations, remittances from home countries as well as wage payments.
Although the innovation was born in East Africa, West Africa has emerged as the new mobile money frontier, where adoption is currently almost 29% of active mobile money accounts in Sub-Saharan Africa are now based, compared to just 8% five years ago.

Markets such as Gabon, Ghana, Kenya, Namibia, Tanzania, Uganda and Zimbabwe have more than 40% of users as active mobile money users.

Sitoyo Lopokoiyit, the director of m-commerce at Vodacom Tanzania said operators will have to look beyond inter-operating with other MNO’s and innovate new services to loop it other players like banks, while deepening the existing ones.

“When I was in China I never even saw their money, all transactions were cashless, it was so efficient, that’s where we should be looking but we can’t achieve this alone as MNO’s, we have to interoperate with other industry players” said Sitoyo.

Only 17% of the viable mobile money rural market has been tapped says GSMA, Tanzania for instance still has up to 92% of its people especially in rural areas still unbanked.

The growing stable of mobile money savings and credit products are quickly changing the way people access soft loans, M-Shwari, the M-Pesa credit product alone has disbursed soft loans amounting to US$1.3 billion since 2012, most of this going to SMES’s. With a non-performing loan ratio of 1.92%, and prohibitive interest rates in banks, adoption will only grow for these credit products.

Mobile money has also been seen as a lifeline to a number of social and economic clusters in Africa, from the increasing number of agents, growing from 100,000 agents in 2011 to 1.5 million in 2016, 47% of revenues from mobile money in the region went to agents.

The wider reach of a mobile phone has proved to be an asset especially in Africa, it’s a multifaceted tool which has been improving people’s lives across the board as the world tries to connect the next billion, to accelerate this, governments have to look far by providing the needed policy support and update the archaic regulations in place.

Originally published in QUARTZ AFRICA

Wednesday, July 26, 2017

NEWS POST: China Builds One Of The World's Largest 'Hack-Proof' Quantum Computer Networks In An Effort To Create A Web That Is 100% Secure

China has built one of the world's largest hack-proof computer networks in a bid to protect state secrets from prying eyes. An advanced communications system will secure government, financial, military and other information from eavesdroppers. (Stock image)
The project in Jinan is aimed at protecting state secrets from prying eyes. Data sent down fibre optic cables will be protected using quantum encryption. Around 200 users can send messages across a 125 mile long (200km) network. Particles of light are distorted or destroyed if anyone tries to tamper with them. This means that the network is secure and will alert users to any attacks

China has built one of the world's largest hack-proof computer networks in a bid to protect state secrets from prying eyes. An advanced communications system will secure government, financial, military and other information from eavesdroppers.

Information sent down fibre optic cables will be safeguarded using quantum encryption so advanced that it cannot be broken by current technology. Such breakthroughs could soon lead to a global quantum web that is 100 per cent secure from hackers.

The upcoming launch of the project in Jinan, in China's eastern Shandong province, was first announced by state media earlier this month after testing of the system was successfully completed. 

The network uses a technique called quantum key distribution to send data securely.

Before a message is sent, a special key is transmitted that is needed to decode the information. Both the key and the data are sent in particles of light, which are distorted or completely destroyed if anyone attempts to tamper with them.

It will also alert both the sender and receiver to the attack. 

This will allow around 200 government workers in the city to transmit messages, across a 125 mile long (200km) network, safe in the knowledge that they cannot be successfully intercepted. A larger 1,250 mile (2,000km) long fibre-optic link from Beijing to Shanghai is planned for completion later this year.

The network has been built by QuantumCTek, based in Hefei in eastern China.

Speaking to The Register (Next Story), CEO Yong Zhao, said: 'We think our tech is secure right now. 'Why do we wait until quantum computers can break classical cryptography?  We know there's no backdoor,' he added of the new network.

The technology represents a leap forward in encryption techniques and anticipates the limitations of current methods. Hackers are increasingly able to circumvent protection efforts, thanks in part to increases in computing power. 

Keys are embedded into photons which are stored as ones or zeroes depending on the polarization of the sub atomic particles. The system has one cable for sharing photons and another for data transfer (Stock image)
Current technology relies on mathematical equations, that are too complex for most computers to crack, to protect our data. But, as processing power continues to grow, these equations have to be made increasingly complex to keep up. And there are fears that the next generation of quantum computers, which will be able to perform vastly more complex tasks, will make this method of protection obsolete. 

The Chinese project sidesteps this issue by using a totally different mechanism.

Keys are embedded into photons which are stored as ones or zeroes depending on the polarization of the sub atomic particles.

The system has one cable for sharing photons and another for data transfer.

This is not the first time China has experimented with quantum technology. In recent weeks, physicists revealed the details on a ground-breaking experiment to achieve ‘ultra-long-distance quantum teleportation,’ which could help to pave the way for a global quantum internet.

In a major breakthrough, the team established the first ground-to-satellite quantum network, which allowed them to transmit a photon from an entangled pair up to 870 miles (1,400 kilometres). Entangled photons theoretically maintain their link across any distance, and have potential to revolutionize secure communications, but scientists have previously only managed to maintain the bond for about 62 miles (100 km). 

Pairs of entangled photons fired to ground stations can form a ‘secret key’ and, theoretically, any attempts to breach this type of communication would be easily detectable. 

In quantum physics, entangled particles remain connected so that actions performed by one affects the behaviour of the other, even if they are separated by huge distances. 
So, if someone were to attempt to listen in on one end, the disruption would be detectable on the other. 

In a major breakthrough, the team established the first ground-to-satellite quantum network, which allowed them to transmit a photon from an entangled pair up to 870 miles (1,400 kilometers). An artist's impression of the Micius 'quantum' satellite is pictured
China's 'Future-Proof' Crypto: We Talk To Firm Behind Crazy Quantum Key Distribution Network

Should we believe the hype? And why drop so much $$?

Two hundred local government employees across the capital of China's eastern Shandong province will soon be encrypting messages with keys that are "impossible" to crack.

QuantumCTek, headquartered in the humid, subtropical city of Hefei in eastern China, will next month launch a commercial network for creating and sharing secure "quantum keys" across 200km2 of Jinan, China. It'll be the first such citywide system in the country, and outside scientists tell us it's likely one of the largest in scale (at least, that isn't top secret) in the world.

The classical encryption we enjoy today in our apps, sites and services has a tiny flaw: it's based on the principles of mathematics. If a computer were able to make an unlimited number of guesses, then it could theoretically discern any key.

Many security professionals call existing government-grade cryptosystems – such as 128-bit or 256-bit AES keys – secure enough for practical purposes. It would take today's computers an infeasible amount of time to find the correct key and then crack private messages open (it's publicly known that the US's National Security Agency can today crack 80-bit encryption, but scientists believe that AES-256, which could require a computer to make up to 2256 guesses, might take 100 years to be feasible to crack.)

QuantumCTek CEO Yong Zhao is worried about the future possibility: quantum computers, which can exploit the mysterious principles of quantum mechanics to perform computations much faster than a classical computer, finding values for keys much more quickly. With one quantum computing algorithm, for example, 256-bit keys could be discerned in 2128 steps or less.

Distributing RSA over a public communication channel might not be secure if RSA could be cracked, Zhao says.

QuantumCTek's new quantum key distribution network, as first reported by China's state news agencies earlier this month, has six "control centres" spread throughout Jinan that facilitate sharing keys hidden inside the states of photons. Like quantum computers, these special keys exploit the principles of quantum mechanics.

In this case, the aim is make them physically unguessable, thus future-proofing encryption done by these keys to possible attack.

"We know there's no backdoor," Zhao told The Register.

(Stock image)
How it works
In the quantum key distribution network, the control centres generate and stores random keys at 10kbps, 24 hours a day. The bits of these keys get stored as 0 or 1 inside the polarization states of photons. By the principles of quantum mechanics, once you measure a photon's state, you can't measure it again without changing the state – so good luck guessing it after it's used!

The system has one fibre for sharing photons and one fibre for data transfer.

For our classic crypto couple Alice and Bob to communicate, they first must receive a secret random number, N, that will be used to help authenticate their interaction via any one of the control centres.

Then, they each generate their own separate sequence of random bits, A1 for Alice and B1 for Bob. Alice and Bob send their respective bits – stored as photon states – to that control centre.

Using four semiconductor photodetectors (about the size "of a small box" – Zhao declined to clarify their size or provide further technical details) – the control centre measures their polarization state and creates new bit sequences, C1 for Alice and C2 for Bob. After doing some postprocessing (C1 and C2 are shorter than the original bits because of fibre losses, channel noise and measurement error) for length and security, the control centre creates a K1 for Alice and K2 for Bob, which it shares with Alice and Bob inside photons.

Next, the control centre encrypts K1 by adding its bits to K2 (called a "one-time pad") and sends K1 to Bob via photons. Now, Bob has K2, so he can decrypt K1 to get it. Hence Bob can use K1 to decrypt any future messages from Alice.

The control centre also shares a third key, K3, with Alice and Bob that will be used in addition to their secret random number for authentication, created the same way.

Alice then encrypts a message with K1, typically by using AES or SM4 (a Chinese encryption standard) or, in cases where extreme security is necessary, using a one-time pad. Alice creates a checksum of this message using the random number, encrypting it with K3.

Alice then sends the K1-encrypted message and K3-encrypted checksum to Bob. Bob uses K1 to decrypt the message, and verifies it came from Alice by decrypting the checksum with K3 and recomputing it using the random number N they'd shared previously.

They send 40 million photons per second, and in the end they get, on average (after processing) a data transfer rate of 4,000bps sent. The longest transfer is about 50km to 60km. Zhao says the system photon loss is about .2 or .3dB per kilometer.

The frequency of key updating depends on the wishes of the users, he says.

From theory to practice
The CEO said the most difficult part of engineering was making the system commercial – to deal with the reality of working in a real environment. The team created a test bed network in 2013, which evolved into the commercial network this year – with 100 test users. Testing finally finished just under three weeks ago, on 30 June.

Zhao said researchers independent from QuantumCTek had evaluated the security of the network (to check for any loopholes) and are preparing a paper on the results of the test bed network. For documentation, he referred The Register to papers on the backend technology published before the testbed network was constructed (see hereherehere and here).

By the end of next month, he says 200 employees in the local Jinan government (which owns the network) will use it for sending text, photos and videos.

He says many researchers are working on using satellites to aid with quantum key distribution or quantum encryption, and he says that "I think we need both" a ground network as well as satellites because of technical difficulties during ground-to-satellite communication (you'd need a satellite for communicating from China to the United Kingdom, for example, because of losses at great distances).

"We think our tech is secure right now," he says. "Why do we wait until quantum computers can break classical cryptography?"

Companies such as NEC and Toshiba are also testing quantum key distribution, while companies such as ID Quantique in Geneva have been offering hardware for quantum key distribution for years. Many research groups are also developing their own quantum communication networks.
(Source: AFP/WIRES/DAILY MAIL)
Originally published (STORY1) on AFP/WIRES/DAILY MAIL and (STORY 2) on THE REGISTER

Saturday, July 22, 2017

NEWS POST: Dutch Students Unveil Autobus Powered By Formic Acid Converted Into Electricity

World's first formic acid-fuelled bus
Ant power: Take a ride on a bus that runs on formic acid: Dutch students unveil the world's first system that converts formic acid into electricity, which is then used to power an autobus.



A group of students has developed a way of storing energy that could be cheaper to make, more practical and more sustainable than alternative renewable fuels.

They are young and clever, and they want to change the world - one bus at a time.

"We've created the world's first bus that runs on formic acid, which is a much cheaper solution than hydrogen, yet it delivers the same environmental benefits," says Lucas van Cappellen from Team Fast, a spin-off company from Eindhoven University of Technology in the Netherlands.

"We're building our own future."
Around 40 of his fellow students are endeavouring to develop emissions-free transport that will help in the global battle against climate change. And they're also trying to create careers for themselves.

Formic acid is found in nature, delivered in the stings and bites of ants and other insects - the Latin word for ant is formica.

And this simple carboxylic acid (chemical formula HCOOH) is already used in textiles and leather processing, as a livestock feed preservative, and is also found in some household limescale removers.

But Team Fast has found a way the acid can efficiently carry the ingredients needed for hydrogen fuel cells, used to power electric vehicles.

The fuel, which the team has dubbed hydrozine (not to be confused with hydrazine), is a liquid, which means you can transport it easily and refill vehicles quickly, as with conventional fuels.

The difference is that it is much cleaner.

"The tailpipe emissions are only CO2 and water," explains Mr van Cappellen. "No other harmful gases like nitric oxides, soot or sulphuric oxides are emitted."

To prove the concept in the real world, an electric bus is set to hit the road in the Netherlands later this year, where it will shuttle between running on conventional bus routes and appearing at promotional events and industry fairs.

The bus has an electric drive system, developed by bus builder VDL, that receives additional power from the formic acid fuel cell system mounted in a range-extender trailer, towed behind.

"Our tank is around 300 litres, so we will extend the range of the bus by 200km (180 miles). However, we could of course make the tank bigger very easily," says Mr van Cappellen.

Current hydrogen fuel cell buses have a range of up to 400km.


But why develop a bus rather than a car?
"If we built a car, we would compete with electric cars, but we believe battery-powered cars are a good solution for a lot of people," says Mr van Cappellen.

"But if we prove that we can build a bus that meets the needs of bus companies, with a range of around 400km and quick refuelling, we will have shown the potential of hydrozine in a segment where there is no sustainable competition yet."

Hydrozine is created through a chemical reaction between water (H2O) and carbon dioxide (CO2).

"In a reactor, water and CO2 are bonded using sustainable electricity. This is a direct, sustainable electrochemical process," explains Mr van Cappellen.

The hydrozine is then broken down by a catalyst into hydrogen and carbon dioxide inside a piece of kit called a reformer that Team Fast is attempting to patent.

Its newly designed reformer is a tenth of the size of reformers of the past, which is why "it is now applicable in transport applications for the first time".

The hydrogen is then added to a fuel cell where it reacts with oxygen to generate the electricity that powers the electric motor.

"We are continuously looking for new technologies that can extend the range of zero emissions traffic in a simple way," says Menno Kleingeld, managing director, VDL


The hydrozine-filled trailer will attach to the back of the bus TEAM FAST
Enabling transport solutions
"The decomposition of formic acid into hydrogen gas is one of these new, promising technologies."

But does it really stand a chance of becoming commercially viable?

"It costs about 35,000 (£30,000) to convert a conventional petrol filling station to a hydrozine filling station, a process that essentially involves replacing the pipes and coating the tanks," says Mr van Cappellen.

As such, it is "100 times cheaper" to roll out a fuelling network for hydrozine than for gaseous hydrogen, he maintains.

"Hydrozine is currently cheaper than petrol and more expensive than diesel in the Netherlands, and in future we expect prices to come down so it will be cheaper than both," he adds.


Some types of ant squirt formic acid as a defence mechanism GETTY IMAGES
Although the bus emits CO2, Team Fast argues that the original CO2 used to create the hydrozine is taken from existing sources, such as air or exhaust fumes, so that no additional CO2 is produced - it's a closed carbon cycle in the jargon.

Some experts believe the technology shows promise.

"Team Fast has a very good project," says Professor Richard van de Sanden, head of the Dutch Institute for Fundamental Energy Research.

"It works on a very important issue: the storing of renewable energy in a transportable form and in a form which can actually be used."

And several companies are supporting the project.

"What we're working on together is a version of renewable energy that can combine renewable energy with CO2 capture," says Martijn de Graaff, senior business development manager at TNO Industry.

"If we achieve this it will give us a stable future."

The students' own commitment is impressive, with 15 of the 40 working full time on the project, and the rest contributing at least 20-25 hours per week.

"We don't get study points for it, but you can only learn so much at university about the practical experience of things," Mr van Cappellen says.

"It's our own future we're making."
How to power a bus on formic acid